Decreased Abundance of Genus Slackia in Individuals With Obesity and Colorectal Adenoma.

ABSTRACT:

Background and aims

The increasing prevalence of obesity has significantly contributed to the global burden of colorectal cancer and the precancerous colorectal adenoma (CRA). Gut microbiota vary at each stage of colorectal carcinogenesis and participate in energy homeostasis. Elucidating gut microbiotal characteristics in obesity-related CRA may help prevent and treat colorectal tumors; however, this remains unclarified. Therefore, this study investigated the gut microbiota profile of patients with obesity-related CRA.

Methods

This hospital setting-based cross-sectional study included 113 participants (66 [without CRA control group] and 37 [with CRA group]; each group was divided into obese and nonobese groups) who underwent screening colonoscopy between June 2019 and Janua

SUBMITTER: Sakai T 

PROVIDER: S-EPMC11330935 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature