Lung-specific supramolecular nanoparticles for efficient delivery of therapeutic proteins and genome editing nucleases.

ABSTRACT: Protein therapeutics play a critical role in treating a large variety of diseases, ranging from infections to genetic disorders. However, their delivery to target tissues beyond the liver, such as the lungs, remains a great challenge. Here, we report a universally applicable strategy for lung-targeted protein delivery by engineering Lung-Specific Supramolecular Nanoparticles (LSNPs). These nanoparticles are designed through the hierarchical self-assembly of metal-organic polyhedra (MOP), featuring a customized surface chemistry that enables protein encapsulation and specific lung affinity after intravenous administration. Our design of LSNPs not only addresses the hurdles of cell membrane impermeability of protein and nonspecific tissue distribution of protein d

SUBMITTER: Liu J 

PROVIDER: S-EPMC11331071 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature