A therapeutic small molecule enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice.

ABSTRACT: Brain rhythms provide the timing for recruitment of brain activity required for linking together neuronal ensembles engaged in specific tasks. The γ-oscillations (30 to 120 Hz) orchestrate neuronal circuits underlying cognitive processes and working memory. These oscillations are reduced in numerous neurological and psychiatric disorders, including early cognitive decline in Alzheimer's disease (AD). Here, we report on a potent brain-permeable small molecule, DDL-920 that increases γ-oscillations and improves cognition/memory in a mouse model of AD, thus showing promise as a class of therapeutics for AD. We employed anatomical, in vitro and in vivo electrophysiological, and behavioral methods to examine the effects of our lead therapeutic candidate small molecule. As a novel in central ner

SUBMITTER: Wei X 

PROVIDER: S-EPMC11331084 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature