Lining the small intestine with mycobacteriophages protects from <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> and eliminates fecal shedding.

ABSTRACT: Johne's disease (JD), a chronic, infectious enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP), affects wild and domestic ruminants. There is no cure or effective prevention, and current vaccines have substantial limitations, leaving this disease widespread in all substantial dairy industries causing economic, and animal welfare implications. Mycobacteriophages (MPs) have been gaining interest in recent years and are proposed as a promising solution to curtailing MAP infection. Using a well-validated infection model, we have demonstrated the preventative potential of MPs to protect dairy calves against MAP infection. Calves were supplemented daily with a phage cocktail from birth till weaning at 2 m of age and inoculated with MAP at 2 wk of age. Infection s

SUBMITTER: Harman-McKenna VK 

PROVIDER: S-EPMC11331133 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature