Calcium influx: An essential process by which α-Synuclein regulates morphology of erythrocytes.

ABSTRACT:

Introduction

Morphological abnormalities of erythrocytes/red blood cells (RBCs), e.g., increased acanthocytes, in Parkinson's disease (PD) have been reported previously, although the underlying mechanisms remain to be characterized. In this study, the potential roles of α-synuclein (α-syn), a protein critically involved in PD and highly abundant in RBCs, were studied in PD patients as well as in a PD mouse model.

Methods

Transgenic [PAC-Tg (SNCA^A53T), A53T] mice overexpressing A53T mutant α-syn and SNCA knockout mice were employed to characterize the effect of α-syn on RBC morphology. In addition to A53T and SNCA knockout mice, the morphology of RBCs of PD patients was also examined using scanning electron microscopy. The potential roles of α-syn were further inve

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11331169 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature