IFP35 aggravates Staphylococcus aureus infection by promoting Nrf2-regulated ferroptosis.

ABSTRACT:

Introduction

Serious Staphylococcus aureus (SA) infection is one of the most life-threatening diseases. Interferon-induced protein 35 (IFP35) is a pleiotropic factor that participates in multiple biological functions, however, its biological role in SA infection is not fully understood. Ferroptosis is a new type of regulated cell death driven by the accretion of free iron and toxic lipid peroxides and plays critical roles in tissue damage. Whether ferroptosis is involved in SA-induced immunopathology and its regulatory mechanisms remain unknown.

Objectives

We aimed to determine the role and underlying mechanisms of IFP35 in SA-induced lung infections.

Methods

SA infection models were established using wild-type (WT) and IFP35 knockout (Ifp35^-/-) mice or mac

SUBMITTER: Dai M 

PROVIDER: S-EPMC11331171 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature