Efficacy and Safety of ¹²⁵I Seed Implantation in the Treatment of Pelvic Recurrent Cervical Cancer Following Radiotherapy: A Single-Arm Meta-Analysis of Chinese Patients.

ABSTRACT:

Background

The study aimed to assess the efficacy and safety of ¹²⁵I seed implantation in the treatment of pelvic recurrent cervical cancer following radiotherapy. This meta-analysis was registered in PROSPERO. We looked up relevant studies in the databases of CNKI, Wanfang, CBM, PubMed, Embase, Cochrane Library, and Web of Science. The endpoint measures include the objective response rate, disease control rate, progression-free survival, overall survival, and adverse events.

Recent fidings

The meta-analysis included six studies and a total of 246 patients. The pooled ORR of tumor response was 63%, and the DCR was 87%. The median PFS was 9.09 months, and the median OS was 13.46 months. The incidence of adverse events of Grade ≥III was 6%.

Conclusion

In conc

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11331501 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature