HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscape.

ABSTRACT:

Background

Histone deacetylases (HDACs) are crucial regulators of gene expression, DNA synthesis, and cellular processes, making them essential targets in cancer research. HDAC6, specifically, influences protein stability and chromatin dynamics. Despite HDAC6's potential therapeutic value, its exact role in gene regulation and chromatin remodeling needs further clarification. This study examines how HDAC6 inactivation influences lysine acetyltransferase P300 stabilization and subsequent effects on chromatin structure and function in cancer cells.

Methods and results

We employed the HDAC6 inhibitor ITF3756, siRNA, or CRISPR/Cas9 gene editing to inactivate HDAC6 in different epigenomic backgrounds. Constantly, this inactivation led to significant changes in chromatin accessibi

SUBMITTER: Zamperla MG 

PROVIDER: S-EPMC11331611 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature