SOX2 interacts with hnRNPK to modulate alternative splicing in mouse embryonic stem cells.

ABSTRACT:

Background

SOX2 is a determinant transcription factor that governs the balance between stemness and differentiation by influencing transcription and splicing programs. The role of SOX2 is intricately shaped by its interactions with specific partners. In the interactome of SOX2 in mouse embryonic stem cells (mESCs), there is a cohort of heterogeneous nuclear ribonucleoproteins (hnRNPs) that contributes to multiple facets of gene expression regulation. However, the cross-talk between hnRNPs and SOX2 in gene expression regulation remains unclear.

Results

Here we demonstrate the indispensable role of the co-existence of SOX2 and heterogeneous nuclear ribonucleoprotein K (hnRNPK) in the maintenance of pluripotency in mESCs. While hnRNPK directly interacts with the SOX2-HMG DNA-bi

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11331657 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature