Risk factors for cognitive decline in non-demented elders with amyloid-beta positivity.

ABSTRACT:

Background

As a currently incurable but preventable disease, the prevention and early diagnosis of Alzheimer's disease (AD) has long been a research hotspot. Amyloid deposition has been shown to be a major pathological feature of AD. Notably, not all the people with amyloid-beta (Aβ) pathology will have significant cognitive declines and eventually develop AD. Therefore, the aim of this study was to explore the risk factors for cognitive decline in Aβ-positive participants.

Methods

We included 650 non-demented participants who were Aβ-positive at baseline from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Mixed effects and COX regression models were applied to assess 37 potential risk factors. Mixed effects models were employed to assess the temporal assoc

SUBMITTER: Wang AY 

PROVIDER: S-EPMC11331665 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature