Association between thermogenic brown fat and genes under positive natural selection in circumpolar populations.

ABSTRACT:

Background

Adaptation to cold was essential for human migration across Eurasia. Non-shivering thermogenesis through brown adipose tissue (BAT) participates in cold adaptation because some genes involved in the differentiation and function of BAT exhibit signatures of positive natural selection in populations at high latitudes. Whether these genes are associated with the inter-individual variability in BAT thermogenesis remains unclear. In this study, we evaluated the potential associations between BAT activity and single nucleotide polymorphisms (SNPs) in candidate gene regions in East Asian populations.

Methods

BAT activity induced by mild cold exposure was measured in 399 healthy Japanese men and women using fluorodeoxyglucose-positron emission tomography and computed tomo

SUBMITTER: Ishida Y 

PROVIDER: S-EPMC11331686 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature