Modified Delphi panel consensus recommendations for management of severe aplastic anemia.

ABSTRACT:

Abstract

Severe aplastic anemia (SAA) is a rare hematologic condition for which there is no clear management algorithm. A panel of 11 experts on adult and pediatric aplastic anemia was assembled and, using the RAND/University of California, Los Angeles modified Delphi panel method, evaluated >600 varying patient care scenarios to develop clinical recommendations for the initial and subsequent management of patients of all ages with SAA. Here, we present the panel's recommendations to rule out inherited bone marrow failure syndromes, on supportive care before and during first-line therapy, and on first-line (initial management) and second-line (subsequent management) therapy of acquired SAA, focusing on when transplant vs medical therapy is most appropriate. These recommendations re

SUBMITTER: Babushok DV 

PROVIDER: S-EPMC11331724 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature