The causal relationship between gut microbiota and constipation: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Constipation is one of the most common gastrointestinal disorders afflicting the population, with recent observational studies implicating dysfunction of the gut microbiota in constipation. Despite observational studies indicating a relationship, a clear causality remains unclear. This study aims to use two-sample Mendelian randomization (MR) to establish a clearer causal relationship between the two.

Methods

A two-sample Mendelian randomization (MR) study was performed using the gut microbiota summary Genome-Wide Association Studies (GWAS) statistics from MiBioGen consortium (n = 13,266) and constipation GWAS summary statistics from the IEU OpenGWAS database. The causality between gut microbiota and constipation is primarily analyzed using the inverse-variance we

SUBMITTER: He N 

PROVIDER: S-EPMC11331768 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature