A back-translational study of descending interactions with the induction of hyperalgesia by high-frequency electrical stimulation in rats and humans.

ABSTRACT:

Abstract

In humans and animals, high-frequency electrocutaneous stimulation (HFS) induces an "early long-term potentiation-like" sensitisation, where synaptic plasticity is underpinned by an ill-defined interaction between peripheral input and central modulatory processes. The relative contributions of these processes to the initial pain or nociceptive response likely differ from those that underpin development of the heightened response. To investigate the impact of HFS-induced hyperalgesia on pain and nociception in perception and neural terms, respectively, and to explore the impact of descending inhibitory pathway activation on the development of HFS-induced hyperalgesia, we performed parallel studies utilising identical stimuli to apply HFS concurrent to (1) a conditioned pain

SUBMITTER: Patel R 

PROVIDER: S-EPMC11331830 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature