Biological and Methodological Variability in Retinal Nerve Fiber Layer OCT: The Framingham Heart Study.

ABSTRACT:

Objective

To explore participant-level biological attributes and scan-level methodological attributes associated with retinal nerve fiber layer (RNFL) thickness variability in a population-based sample of elderly United States adults.

Design

Cross-sectional analysis using data from the Framingham Heart Study.

Participants

One thousand three hundred forty-seven eyes from 825 participants with ≥1 OCT scan and axial length data were included.

Methods

Three or more successive RNFL scans of each eye of each participant were obtained in a single session. Multivariable linear mixed models were employed to explore the associations between average RNFL thickness with participant-level biological attributes (age, gender, race, ethnicity, and axial length) and scan-level

SUBMITTER: Almidani L 

PROVIDER: S-EPMC11331915 | biostudies-literature | 2024 Nov-Dec

REPOSITORIES: biostudies-literature