Deciphering the enigmatic PilY1 of Acidithiobacillus thiooxidans: An in silico analysis.

ABSTRACT: Thirty years since the first report on the PilY1 protein in bacteria, only the C-terminal domain has been crystallized; there is no study in which the N-terminal domain, let alone the complete protein, has been crystallized. In our laboratory, we are interested in characterizing the Type IV Pili (T4P) of Acidithiobacillus thiooxidans. We performed an in silico characterization of PilY1 and other pilins of the T4P of this acidophilic bacterium. In silico characterization is crucial for understanding how proteins adapt and function under extreme conditions. By analyzing the primary and secondary structures of proteins through computational methods, researchers can gain valuable insights into protein stability, key structural features, and unique amino acid compositions t

SUBMITTER: Hernandez-Sanchez A 

PROVIDER: S-EPMC11331964 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature