Single-cell transcriptomic analysis of immune cell dynamics in the healthy human endometrium.

ABSTRACT: The microenvironment of the endometrial immune system is crucial to the success of placental implantation and healthy pregnancy. However, the functionalities of immune cells across various stages of the reproductive cycle have yet to be fully comprehended. To address this, we conducted advanced bioinformatic analysis on 230,049 high-quality single-cell transcriptomes from healthy endometrial samples obtained during the proliferative, secretory, early pregnancy, and late pregnancy stages. Our investigation has unveiled that proliferative natural killer (NK) cells, a potential source of endometrial NK cells, exhibit the most robust proliferative and differentiation potential during non-pregnant stages. We have also identified similar differentiation trajectories of NK cells originating from

SUBMITTER: Chen K 

PROVIDER: S-EPMC11332207 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature