Bioinformatic prediction of proteins relevant to functions of the bacterial OLE ribonucleoprotein complex.

ABSTRACT: OLE (ornate, large, extremophilic) RNAs are members of a noncoding RNA class present in many Gram-positive, extremophilic bacteria. The large size, complex structure, and extensive sequence conservation of OLE RNAs are characteristics consistent with the hypothesis that they likely function as ribozymes. The OLE RNA representative from Halalkalibacterium halodurans is known to localize to the phospholipid membrane and requires at least three essential protein partners: OapA, OapB, and OapC. However, the precise biochemical functions of this unusual ribonucleoprotein (RNP) complex remain unknown. Genetic disruption of OLE RNA or its partners revealed that the complex is beneficial under diverse stress conditions. To search for additional links between OLE RNA and other cellular compo

SUBMITTER: Fernando CM 

PROVIDER: S-EPMC11332333 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature