Relationship between functional connectivity and weight-gain risk of antipsychotics in schizophrenia.

ABSTRACT:

Background

The mechanisms by which antipsychotic medications (APs) contribute to obesity in schizophrenia are not well understood. Because AP effects on functional brain connectivity may contribute to weight effects, the current study investigated how AP-associated weight-gain risk relates to functional connectivity in schizophrenia.

Methods

Fifty-five individuals with schizophrenia (final N = 54) were divided into groups based on previously reported AP weight-gain risk (no APs/low risk [N = 19]; moderate risk [N = 17]; high risk [N = 18]). Resting-state functional magnetic resonance imaging (fMRI) was completed after an overnight fast ("fasted") and post-meal ("fed"). Correlations between AP weight-gain risk and functional connectivity were assessed at the whole-brain level

SUBMITTER: Dodd K 

PROVIDER: S-EPMC11332974 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature