Veillonella parvula promotes root caries development through interactions with Streptococcus mutans and Candida albicans.

ABSTRACT: Root caries is a subtype of dental caries that predominantly impacts older adults. The occurrence and progression of root caries are associated with the homeostasis of dental plaque biofilm, and microbial synergistic and antagonistic interactions in the biofilm play a significant role in maintaining the oral microecological balance. The objective of the current study was to investigate the role of Veillonella parvula in the microbial interactions and the pathogenesis of root caries. The analysis of clinical samples from patients with/without root caries revealed that Veillonella and V. parvula were abundant in the saliva of patients with root caries. More importantly, a significantly increased colonization of V. parvula was observed in root carious lesions. Further in vitro biofilm and ani

SUBMITTER: Li G 

PROVIDER: S-EPMC11333197 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature