Pyridylpiperazine-based carbodithioates as urease inhibitors: synthesis and biological evaluation.

ABSTRACT: The urease enzyme is recognized as a valuable therapeutic agent for treating the virulent Helicobacter pylori bacterium because of its pivotal role in aiding the colonization and growth of the bacterium within the gastric mucosa. In order to control the harmful consequences of bacterial infections, urease inhibition presents itself as a promising and effective approach. The current research aimed to synthesize pyridylpiperazine-based carbodithioate derivatives 5a-5n and 7a-7n that could serve as potential drug candidates for preventing bacterial infections through urease inhibition. The synthesized carbodithioate derivatives 5a-5n and 7a-7n were explored to assess their ability to inhibit the urease enzyme after their structural explication by gas chromat

SUBMITTER: Akash M 

PROVIDER: S-EPMC11333205 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature