Integrating polygenic risk scores in the prediction of gestational diabetes risk in China.

ABSTRACT:

Background

Polygenic risk scores (PRS) serve as valuable tools for connecting initial genetic discoveries with clinical applications in disease risk estimation. However, limited studies have explored the association between PRS and gestational diabetes mellitus (GDM), particularly in predicting GDM risk among Chinese populations.

Aim

To evaluate the relationship between PRS and GDM and explore the predictive capability of PRS for GDM risk in a Chinese population.

Methods

A prospective cohort study was conducted, which included 283 GDM and 2,258 non-GDM cases based on demographic information on pregnancies. GDM was diagnosed using the oral glucose tolerance test (OGTT) at 24-28 weeks. The strength of the association between PRS and GDM odds was assessed employing odds

SUBMITTER: Cheng J 

PROVIDER: S-EPMC11333217 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature