Association between exposure to organophosphate flame retardants and epidermal growth factor receptor expression in lung cancer patients.

ABSTRACT:

Background

Organophosphate flame retardants (OPFRs) are extensively distributed in our environment, prompting concerns about potential health hazards, including lung injuries resulting from OPFR exposure.

Methods

The present study recruited 125 lung cancer patients, assessing their exposure to 10 OPFR compounds through urine samples. The final analysis comprised 108 participants after excluding those lacking epidermal growth factor receptor (EGFR) status and those with chronic kidney disease. Demographic and clinical characteristics, as well as urinary OPFR concentrations, were compared based on OPFR detection. Spearman correlation was conducted to explore the relationship between OPFR compounds, while logistic regression was used to identify OPFR compounds associated with E

SUBMITTER: Chen PJ 

PROVIDER: S-EPMC11333296 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature