Exploring the genetic and socioeconomic interplay between ADHD and anxiety disorders using Mendelian randomization.

ABSTRACT:

Background

ADHD and anxiety disorders often co-occur, sharing symptoms and dysfunctions, yet the underlying mechanisms remain elusive.

Methods

To explore the shared and distinct genetic variations between ADHD and anxiety disorders, we applied Mendelian randomization (MR) analysis to ADHD, anxiety disorders, and three socioeconomic factors: income, educational attainment (EA), and intelligence. MR analysis utilized genome-wide association study summary datasets (anxiety disorder: 7,016 cases and 14,745 controls; ADHD: 38,691 cases and 275,986 controls; EA: 766,345 participants; intelligence: 146,808 participants; household income: 392,422 participants), with inverse-variance weighting as the primary method.

Results

Our MR analysis revealed no discernible genetic-level

SUBMITTER: Deng X 

PROVIDER: S-EPMC11333326 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature