Association of gut microbiota with lactose intolerance and coeliac disease: a two-sample Mendelian randomization study.

ABSTRACT:

Background and objectives

Lactose intolerance and coeliac disease are common clinical nutrient malabsorption disorders, with an unclear pathogenesis and limited therapeutic options. It is widely believed that the gut microbiota plays an important role in many digestive disorders, but its role in lactose intolerance and coeliac disease is not yet clear. This study aimed to investigate the correlation between gut microbiota and lactose intolerance and coeliac disease.

Materials and methods

This study utilized the genome-wide association study database to investigate the association between gut microbiota and lactose intolerance and coeliac disease using Mendelian randomization (MR). The robustness of our findings was confirmed through subsequent analyses including Cochrane's <

SUBMITTER: Han Z 

PROVIDER: S-EPMC11333455 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature