Revealing the link between gut microbiota and brain tumor risk: a new perspective from Mendelian randomization.

ABSTRACT:

Background

Recent studies have shown that gut microbiota may be related to the occurrence of brain tumors, but direct evidence is lacking. This study used the Mendelian randomization study (MR) method to explore the potential causal link between gut microbiota and brain tumors.

Method

We analyzed the genome-wide association data between 211 gut microbiota taxa and brain tumors, using the largest existing gut microbiota Genome-Wide Association Studies meta-analysis data (n=13266) and combining it with brain tumor data in the IEU OpenGWAS database. We use inverse-variance weighted analysis, supplemented by methods such as Mendelian randomization-Egger regression, weighted median estimator, simple mode, and weighted mode, to assess causality. In addition, we also conducted the

SUBMITTER: Yang J 

PROVIDER: S-EPMC11333460 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature