Cancer risk in individuals with polydactyly: a Swedish population-based cohort study.

ABSTRACT:

Background

Polydactyly is a feature of several cancer predisposition syndromes (CPS), however, cancer risk in individuals with polydactyly is largely unknown.

Methods

We performed a matched cohort study using data from Swedish national registers. We included 6694 individuals with polydactyly, born in Sweden between 1970-2017. Polydactyly was categorised as thumb polydactyly, finger polydactyly, polydactyly+ (additional birth defects and/or intellectual disability) or isolated polydactyly. Each exposed individual was matched to 50 comparisons by sex, birth year and birth county. Associations were estimated through Cox proportional hazard models.

Findings

An increased childhood cancer risk was found in males (HR 4.24, 95% CI 2.03-8.84) and females (HR 3.32, 95% CI 1.44-

SUBMITTER: Wachtmeister A 

PROVIDER: S-EPMC11333495 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature