Sweetened caffeine drinking revealed behavioral rhythm independent of the central circadian clock in male mice.

ABSTRACT: Caffeine consumption is associated with the evening chronotype, and caffeine administration in mice results in prolonged period of the circadian rhythm in locomotor activity. However, as caffeine is bitter, sweetened caffeine is preferred by humans and mice; yet, its impact on the circadian clock has not been explored. In this study, mice were provided with freely available sweetened caffeine to investigate its effects on behavioral rhythms and peripheral clocks. Mice that freely consumed sweetened caffeine shifted from nocturnal to diurnal activity rhythms. In addition to the light-dark entrained behavioral rhythm component, some animals exhibited free-running period longer than 24-h. Intraperitoneal administration of caffeine at the beginning of the light phase also acutely induced diurn

SUBMITTER: Tahara Y 

PROVIDER: S-EPMC11333706 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature