Illness-related variables and abnormalities of resting-state brain activity in schizophrenia.

ABSTRACT:

Background

The development of neuroimaging biomarkers in patients with schizophrenia (SCZ) requires a refined clinical characterization. A limitation of the neuroimaging literature is the partial uptake of progress in characterizing disease-related features, particularly negative symptoms (NS) and cognitive impairment (CI). In the present study, we assessed NS and CI using up-to-date instruments and investigated the associations of abnormalities in brain resting-state (rs)-activity with disease-related features.

Methods

Sixty-two community-dwelling SCZ subjects participated in the study. Multiple regression analyses were performed with the rs-activity of nine regions of interest as dependent variables and disease-related features as explanatory variables.

Results

Atte

SUBMITTER: Giuliani L 

PROVIDER: S-EPMC11333936 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature