Cellular uptake and viability switching in the properties of lipid coated carbon quantum dots for potential bioimaging and therapeutics.

ABSTRACT: Carbon quantum dots derived from mango leaves exhibited red fluorescence. These negatively charged particles underwent coating with the positively charged lipid molecule N-[1-(2,3-dioleyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTMA). However, the bioconjugate displayed reduced uptake compared to the standalone mQDs in cancer cells (SUM 159A), and increased uptake in case of non-cancerous (RPE-1) cells. Upon in vitro testing, the bioconjugate demonstrated a mitigating effect on the individual toxicity of both DOTMA and mQDs in SUM-159 (cancerous cells). Conversely, it exhibited a proliferative effect on RPE-1 (normal cells).

SUBMITTER: Jain S 

PROVIDER: S-EPMC11333955 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature