MI-181 Modulates Cilia Length and Restores Cilia Length in Cells with Defective Shortened Cilia.

ABSTRACT: Primary cilia are membrane-covered microtubule-based structures that protrude from the cell surface and are critical for cell signaling and homeostasis during human development and adulthood. Dysregulation of cilia formation, length, and function can lead to a spectrum of human diseases and syndromes known as ciliopathies. Although some genetic and chemical screens have been performed to define important factors that modulate cilia biogenesis and length control, there are currently no clinical treatments that restore cilia length in patients. We report that the microtubule-targeting agent MI-181(mitotic inhibitor-181) is a potent modulator of cilia length and biogenesis. Treatment of retinal pigment epithelial-1 cells with MI-181 induced an increase in the average size of cilia and in the

SUBMITTER: Gholkar AA 

PROVIDER: S-EPMC11334112 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature