Causal relationship between gut microbiota and diabetic complications: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Imbalances in gut microbiota (GM) have been proposed as a potential contributing factor to diabetic complications; however, the causal relationship remains incompletely understood.

Methods

Summary statistics were obtained from genome-wide association studies (GWAS) of 196 gut microbial taxa, including 9 phyla, 16 classes, 20 orders, 32 families, and 119 genera. These data were then analyzed using mediation Mendelian randomization (MR) analyses to explore the potential mediating effect of diabetes complications risk factors on the relationship between gut microbiota and specific diabetic complications such as diabetic kidney disease (DKD), ketoacidosis, and diabetic retinopathy (DR).

Results

In our Mendelian analysis, we observed negative associations betwee

SUBMITTER: Liu J 

PROVIDER: S-EPMC11334315 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature