Biomarkers for congenital ventricular outflow tract malformations based on maternal serum lipid metabolomics analysis.

ABSTRACT:

Background

The congenital ventricular outflow tract malformations (CVOTMs) is a major congenital heart diseases (CHDs) subtype, and its pathogenesis is complex and unclear. Lipid metabolic plays a crucial role in embryonic cardiovascular development. However, due to the limited types of detectable metabolites in previous studies, findings on lipid metabolic and CHDs are still inconsistent, and the possible mechanism of CHDs remains unclear.

Methods

The nest case-control study obtained subjects from the multicenter China Teratology Birth Cohort (CTBC), and maternal serum from the pregnant women enrolled during the first trimester was utilized. The subjects were divided into a discovery set and a validation set. The metabolomics of CVOTMs and normal fetuses were analyzed by ta

SUBMITTER: Yuan X 

PROVIDER: S-EPMC11334326 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature