Unmasking of molecular players: proteomic profiling of vitreous humor in pathologic myopia.

ABSTRACT:

Background

This study aimed to identify the differentially expressed proteins in the vitreous humor (VH) of eyes with and without pathologic myopia (PM), providing insights into the molecular pathogenesis.

Methods

A cross-sectional, observational study was conducted. VH samples were collected from patients undergoing vitrectomy for idiopathic epiretinal membrane (ERM), macular hole (MH), or myopic retinoschisis (MRS). Label-free quantitative proteomic analysis identified differential protein expression, with validation using ELISA.

Results

The proteomic profiling revealed significantly higher expressions of tubulin alpha 1a (TUBA1A) and eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) in PM groups (MH-PM, MRS-PM) compared to controls (MH, ERM). Conversely,

SUBMITTER: Wen Y 

PROVIDER: S-EPMC11334356 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature