Gestational DNA methylation age as a marker for fetal development and birth outcomes: findings from the Boston Birth Cohort.

ABSTRACT:

Background

Gestational DNA methylation age (GAmAge) has been developed and validated in European ancestry samples. Its applicability to other ethnicities and associations with fetal stress and newborn phenotypes such as inflammation markers are still to be determined. This study aims to examine the applicability of GAmAge developed from cord blood samples of European decedents to a racially diverse birth cohort, and associations with newborn phenotypes.

Methods

GAmAge based on 176 CpGs (Haftorn GAmAge) was calculated for 940 children from a US predominantly urban, low-income, multiethnic birth cohort. Cord blood DNA methylation was profiled by Illumina EPIC array. Newborn phenotypes included anthropometric measurements and, for a subset of newborns (N = 194), twenty-seven co

SUBMITTER: Yaskolka Meir A 

PROVIDER: S-EPMC11334360 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature