The causal effect of gut microbiota on hepatic encephalopathy: a mendelian randomization analysis.

ABSTRACT:

Background

There is growing evidence for a relationship between gut microbiota and hepatic encephalopathy (HE). However, the causal nature of the relationship between gut microbiota and HE has not been thoroughly investigated.

Method

This study utilized the large-scale genome-wide association studies (GWAS) summary statistics to evaluate the causal association between gut microbiota and HE risk. Specifically, two-sample Mendelian randomization (MR) approach was used to identify the causal microbial taxa for HE. The inverse variance weighted (IVW) method was used as the primary MR analysis. Sensitive analyses were performed to validate the robustness of the results.

Results

The IVW method revealed that the genus Bifidobacterium (OR = 0.363, 95% CI: 0.139-0.943, P = 0.0

SUBMITTER: Wu JL 

PROVIDER: S-EPMC11334368 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature