Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1^highCD206⁺ pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis.

ABSTRACT:

Background

Information transmission between primary tumor cells and immunocytes or stromal cells in distal organs is a critical factor in the formation of pre-metastatic niche (PMN). Understanding this mechanism is essential for developing effective therapeutic strategy against tumor metastasis. Our study aims to prove the hypothesis that circ-0034880-enriched tumor-derived extracellular vesicles (TEVs) mediate the formation of PMN and colorectal cancer liver metastasis (CRLM), and targeting circ-0034880-enriched TEVs might be an effective therapeutic strategy against PMN formation and CRLM.

Methods

We utilized qPCR and FISH to measure circRNAs expression levels in human CRC plasma, primary CRC tissues, and liver metastatic tissues. Additionally, we employed immunofluorescen

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11334400 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature