Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome.

ABSTRACT: Bacterial relatedness measured using select chromosomal loci forms the basis of public health genomic surveillance. While approximating vertical evolution through this approach has proven exceptionally valuable for understanding pathogen dynamics, it excludes a fundamental dimension of bacterial evolution-horizontal gene transfer. Incorporating the accessory genome is the logical remediation and has recently shown promise in expanding epidemiological resolution for enteric pathogens. Employing k-mer-based Jaccard index analysis, and a novel genome length distance metric, we computed pangenome (i.e., core and accessory) relatedness for the globally important pathogen Salmonella enterica serotype Typhi (Typhi), and graphically express both vertical (homology-by-descent) and hor

SUBMITTER: Penil-Celis A 

PROVIDER: S-EPMC11334464 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature