The deubiquitinase USP15 drives malignant progression of gastric cancer through glucose metabolism remodeling.

ABSTRACT:

Background

Ubiquitin-specific protease 15 (USP15) exhibits amplifications in various tumors, including gastric cancer (GC), yet its biological function and mechanisms in GC progression remain elusive.

Methods

Here, we established stable USP15 knockdown or overexpression GC cell lines and explored the potential mechanism of USP15 in GC. Besides, we also identified interacting targets of USP15.

Results

USP15 knockdown significantly impeded cell proliferation, invasion, epithelial-mesenchymal transition, and distal colonization in xenograft models, while enhancing oxaliplatin's antitumor effect. USP15 was involved in ubiquitination modification of glycolytic regulators. Silencing of USP15 suppressed glycolytic activity and impaired mitochondrial functions. Interference w

SUBMITTER: Huangfu L 

PROVIDER: S-EPMC11334570 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature