Oxidative damage and cell cycle delay induced by vanadium(III) in human peripheral blood cells.

ABSTRACT: Vanadium (V) is a metal that can enter the environment through natural routes or anthropogenic activity. In the atmosphere, V is present as V oxides, among which vanadium(III) oxide (V₂O₃) stands out. Cytogenetic studies have shown that V₂O₃ is genotoxic and cytostatic and induces DNA damage; however, the molecular mechanisms leading to these effects have not been fully explored. Therefore, we treated human peripheral blood lymphocytes in vitro, evaluated the effects of V₂O₃ on the phases of the cell cycle and the expression of molecules that control the cell cycle and examined DNA damage and the induction of oxidative stress. The results revealed that V₂O₃ did not affect cell viability at the di

SUBMITTER: Alcantara-Mejia VA 

PROVIDER: S-EPMC11334674 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature