Comprehensive pan-cancer analysis of ACSS3 as a biomarker for prognosis and immunotherapy response.

ABSTRACT:

Background

ACSS3 (acyl-CoA synthetase short-chain family member 3) is found in numerous tissues and is linked to tumor cell type development and metastasis.

Methods

We conducted a comprehensive pan-cancer analysis of ACSS3. The TCGA (Cancer Genome Atlas), CPTAC (Clinical Proteomic Tumor Analysis Consortium), and HPA databases were used to ascertain the connection between ACSS3 and various types of tumors. Genes in the TCGA database would be identified using cBioPortal queries, and their transcriptome expression would then be verified using GEO data. ACSS3 expression and cellular localization in various tumor tissues of most cancer types were analyzed using single-cell sequencing data from the TISCH database. According to HPA and CPTAC databases, we analyzed and evaluated pro

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11334676 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature