Biomimetic design and integrated biofabrication of an in-vitro three-dimensional multi-scale multilayer cortical model.

ABSTRACT: The lack of accurate and reliable in vitro brain models hinders the development of brain science and research on brain diseases. Owing to the complex structure of the brain tissue and its highly nonlinear characteristics, the construction of brain-like in vitro tissue models remains one of the most challenging research fields in the construction of living tissues. This study proposes a multi-scale design of a brain-like model with a biomimetic cortical structure, which includes the macroscopic structural features of six layers of different cellular components, as well as micrometer-scale continuous fiber structures running through all layers vertically. To achieve integrated biomanufacturing of such a complex multi-scale brain-like model, a multi-material composite printing/c

SUBMITTER: Wang L 

PROVIDER: S-EPMC11334787 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature