Overexpression of METTL14 mediates steatohepatitis and insulin resistance in mice.

ABSTRACT:

Background

Lipid accumulation and redox imbalance, resulting from dysregulation of hepatic fatty acids oxidation, contribute to the development of steatohepatitis and insulin resistance. Recently, dysregulated RNA N⁶-methyladenosine (m⁶A) methylation modification has been found involving fatty liver. However, the role of methyltransferase-like 14 (METTL14), the core component of m⁶A methylation, in the development of steatohepatitis is unknown. Herein, we aimed to explore the role of METTL14 on steatohepatitis and insulin resistance in mice with metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods

The liver tissues of mice and patients with MASLD were collected to detect the expression of METTL14. METTL14 overexpression a

SUBMITTER: Zhou JX 

PROVIDER: S-EPMC11334898 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature