Severe lower respiratory tract infections are associated with human adenovirus in hospitalised children in a high HIV prevalence area.

ABSTRACT:

Background

Viral causes of lower respiratory tract infections (LRTIs) are associated with increased mortality in children aged <5 years (U5). Human adenovirus (HAdV) has been associated with severe LRTI; however, its relationship with HIV and malnutrition in South Africa (SA) is not understood.

Objectives

To identify the prevalence of and factors associated with HAdV LRTIs in hospitalised U5 childen.

Methods

Clinical and viral data on U5 children hospitalised with severe LRTI from January 2018 to June 2020 at King Edward VIII Hospital, Durban, SA, including results of a multiplex polymerase chain reaction (PCR) panel assay for respiratory viruses, were retrieved from inpatient files and laboratory databases and retrospectively analysed. Standard descriptive statistics

SUBMITTER: Marafungana N 

PROVIDER: S-EPMC11334900 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature