Genetic variants of m⁶A modification genes are associated with survival of HBV-related hepatocellular carcinoma.

ABSTRACT: N⁶-methyladenosine (m⁶A) is a dynamic and reversible modification process involving in a series of important biological and pathophysiological processes, including the progression of cancers. Herein, we aimed to assess the relationships of genetic variants in m6A modification genes with the survival of hepatitis B virus -related hepatocellular carcinoma (HBV-HCC). We performed a two-stage survival analysis to investigate the associations of 4425 single nucleotide polymorphisms (SNPs) in 36 m⁶A modification genes with the overall survival (OS) of HBV-HCC patients. Then, the identified SNPs were further used to functionally annotate. We identified that METTL3 rs1263790 (A > G) and ADARB1 rs57884102 (C > T) were significantly associated with the HBV-HCC OS (ha

SUBMITTER: Liu S 

PROVIDER: S-EPMC11335057 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature