Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome.

ABSTRACT: Pregnant women undergoing a cesarean section (CS) typically receive antibiotics prior to skin incision to prevent infections. To investigate if the timing of antibiotics influences the infant gut microbiome, we conducted a randomized controlled trial (NCT06030713) in women delivering via a scheduled CS who received antibiotics either before skin incision or after umbilical cord clamping. We performed a longitudinal analysis on 172 samples from 28 infants at 8 post-birth time points and a cross-sectional analysis at 1 month in 79 infants from 3 cohorts. Although no significant associations with bacterial composition, metabolic pathways, short-chain fatty acids, and bile acids were found, we observed subtle differences between the groups at the bacterial strain level and in the load of antib

SUBMITTER: Sinha T 

PROVIDER: S-EPMC11335186 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature