WTAP and m⁶A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells.

ABSTRACT: N⁶-methyladenosine (m⁶A) is one of the most prevalent and conserved RNA modifications. It controls several biological processes, including the biogenesis and function of circular RNAs (circRNAs), which are a class of covalently closed-single stranded RNAs. Several studies have revealed that proteotoxic stress response induction could be a relevant anticancer therapy in Acute Myeloid Leukemia (AML). Furthermore, a strong molecular interaction between the m⁶A mRNA modification factors and the suppression of the proteotoxic stress response has emerged. Since the proteasome inhibition leading to the imbalance in protein homeostasis is strictly linked to the stress response induction, we investigated the role of Bortezomib (Btz) on m⁶A regulation and

SUBMITTER: Iaiza A 

PROVIDER: S-EPMC11335200 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature