AIM2 enhances Candida albicans infection through promoting macrophage apoptosis via AKT signaling.

ABSTRACT: Candida albicans is among the most prevalent invasive fungal pathogens for immunocompromised individuals and novel therapeutic approaches that involve immune response modulation are imperative. Absent in melanoma 2 (AIM2), a pattern recognition receptor for DNA sensing, is well recognized for its involvement in inflammasome formation and its crucial role in safeguarding the host against various pathogenic infections. However, the role of AIM2 in host defense against C. albicans infection remains uncertain. This study reveals that the gene expression of AIM2 is induced in human and mouse innate immune cells or tissues after C. albicans infection. Furthermore, compared to their wild-type (WT) counterparts, Aim2^-/- mice surprisingly exhibit resistance to C. albicans infection, alon

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC11335202 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature