Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez-Hernandez I
PROVIDER: S-EPMC11335212 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Hernández-Hernández Irene I De La Rosa Juan V JV Martín-Rodríguez Patricia P Díaz-Sarmiento Mercedes M Recio Carlota C Guerra Borja B Fernández-Pérez Leandro L León Theresa E TE Torres Rosa R Font-Díaz Joan J Roig Angela A de Mora Fernando F Boscá Lisardo L Díaz Mario M Valledor Annabel F AF Castrillo Antonio A Tabraue Carlos C
Cellular and molecular life sciences : CMLS 20240706 1
Lung type 2 pneumocytes (T2Ps) and alveolar macrophages (AMs) play crucial roles in the synthesis, recycling and catabolism of surfactant material, a lipid/protein fluid essential for respiratory function. The liver X receptors (LXR), LXRα and LXRβ, are transcription factors important for lipid metabolism and inflammation. While LXR activation exerts anti-inflammatory actions in lung injury caused by lipopolysaccharide (LPS) and other inflammatory stimuli, the full extent of the endogenous LXR t ...[more]