CD74 is a functional MIF receptor on activated CD4⁺ T cells.

ABSTRACT: Next to its classical role in MHC II-mediated antigen presentation, CD74 was identified as a high-affinity receptor for macrophage migration inhibitory factor (MIF), a pleiotropic cytokine and major determinant of various acute and chronic inflammatory conditions, cardiovascular diseases and cancer. Recent evidence suggests that CD74 is expressed in T cells, but the functional relevance of this observation is poorly understood. Here, we characterized the regulation of CD74 expression and that of the MIF chemokine receptors during activation of human CD4⁺ T cells and studied links to MIF-induced T-cell migration, function, and COVID-19 disease stage. MIF receptor profiling of resting primary human CD4⁺ T cells via flow cytometry revealed high surface expression of CXCR

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11335222 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature